The First Workshop Program

Tuesday 26th May 2015


Welcome of the participants and coffee


Opening of the Session and Introduction

Chair persons : Hervé Perron & Jean-Louis Touraine

Introductory Presentation


Cédric Feschotte – Department of Human Genetics, University of Utah, USA
Of Good and Evil : Biological Impact of Endogenous Retroviruses and Other Invasive Genetic Elements

Neurological Diseases and HERVs

Chairpersons : Avindra Nath & Guilherme Sciascia do Olival


Avindra Nath- NIH, NINDS, Bethesda, USA
Amyotrophic Lateral Sclerosis and HERV-K


Hervé Perron- GeNeuro Innovation, Lyon, France
From the first retroviral detection in Multiple Sclerosis (MSRV) to the human endogenous retrovirus type W family (HERV-W), the association with disease and the identification of env-encoded pathogenic effector as a therapeutic target in vitro and in vivo models

Patrick Küry – University of Düsseldorf, Germany
Remyelination impairment and HERV-W in Multiple Sclerosis

Patrice Marche – U823 INSERM- University of Grenoble, France
Inflammatory response of endothelial cells to HERV-W Envelope

Antonina Dolei – University of Sassari, Italy
HERV-W/MSRV/Syncytin-1 activation and multiple sclerosis triggers : the EBV/MSRV dual virus hypothesis

Jack van Horssen- VU-University, Amsterdam, The Netherlands
HERV-W Env and Gag immunohistology in cohorts of MS and control brains

John Kriesel – University of Utah, USA
HERV RNA in MS brain

Ranjan Dutta – Cleveland Clinic, Ohio, USA
HERVs in Progressive Multiple Sclerosis

Guilherme Sciascia do Olival – University of Sao Paulo, Brazil
HERV-W/MRSV envelope transcripts detection in blood of multiple sclerosis patients after Natalizumab treatment

Alain Créange – University Hospital Henri Mondor, Créteil, France
Chronic Inflammatory Demyelinating Polyneuropathies and HERV-W

Raphaël Faucard – GeNeuro Innovation, France
MSRV envelope protein is a highly potent agonist of human TLR4: relevance of GNbAC1 in Chronic Inflammatory Demyelinating Diseases treatment

Alexander Emmer & Malte Kornhuber – Martin-Luther-University Halle-Wittenberg, Germany
HERV encoded envelope proteins – key players in autoimmunity ?

Hervé Porchet – GeNeuro SA, Switzerland;
GNbAC1, a humanized IgG4 antibody neutralizing HERV-W Envelope protein; pre-clinical development and Results from Phase I/IIa clinical trials in Healthy volunteers and in MS patients

General discussion
Chairpersons : Patrick Küry & Cedric Feschotte

Conclusions and end of the session
Chairpersons : Patrice Marche & Hervé Perron



Wednesday 27th May 2015

Welcome of the participants and coffee

Introductory Presentation

Chairpersons : Antonina Dolei & Patrice Marche

Frédéric Arnaud – University of Lyon, France and MRC-Center for Virus Research, Glasgow-UK
“Friendly viruses”: antiviral activities of ERVs against the oncogenic Jaagsiekte sheep retrovirus,  the etiologic agent responsible for ovine pulmonary adenocarcinoma in sheep
Virus interplay with HERV Pathogeny
Elena Uleri – University of Sassari, Italy
HERV-W/Syncytin- 1 regulation by HIV-tat in blood and brain cells is mediated by Toll-like receptor 4 and TNF-alpha: inference for neuroAIDS
Benjamin Charvet – International Center for Infectiology Research/INSERM U1111/ENS/University of Lyon, France HHV-6A infection induces the expression of HERV-W envelope in human cells

Neuropsychiatric Diseases and HERVs

Chairpersons : Hakan Kalsson & Laurent Groc

Hakan Karlsson- Karolinska Institute, Sweden HERV-W in Schizophenia
Laurent Groc – University of Bordeaux, France
Molecular imaging and specific neuronoglial reactivity to HERV-W Envelope
Nora Hamdani – APHP & University of Créteil, France Inflammatory psychoses and HERV-W
Chiara Cipriani – University of Rome & Istituto Superiore di Sanita, Italy Transcriptional activity of different endogenous retrovirus families in a mouse model of autism

Diabetes and HERVs

Chairperson : Marion Schneider

13h40-14h05 Marion Schneider – University of Ulm, Germany
HERV-W expression in immature dendritic cells from diabetes
14h05-14h30 Julie Medina – GeNeuro Innovation, Lyon, France
Jacques Portoukalian – University of Lyon, France
Human Endogenous Retrovirus type W is strongly upregulated in T1D pancreas and dysregulates insulin production in vitro and in vivo

Cancer and HERVs

Chairperson : François Mallet

François Mallet – BioMérieux, Hospices Civils de Lyon, France
From sketches of the HERV transcriptome landscape to the clinical evidence of HERV-H specific retroviruses expression in colorectal carcinoma
Reiner Strick – University Clinic Erlangen, Germany
Dysregulation of ERV genes in human pituitary adenoma and glioblastoma multiforme : Possible
functional role in giant-cell glioblastoma
Claudia Matteucci – University of Rome & National Research Council, Italy
Involvement of HERV-K in stemness and malignancy of human melanoma
Martin Staege – Martin-Luther-University Halle-Wittenberg, Germany
HERVs and Hodgkins-lymphoma
General Discussion
Chaipersons : Hervé Perron & François Mallet
Conclusions and End of the meeting
Chairpersons : Patrice Marche, François Curtin & Hervé Perron

(The name of speakers is given for presentations. All authors will be mentioned with titles in the abstract book)


By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.