The First Workshop Program 2015

Tuesday 26th May 2015


Welcome of the participants and coffee


Opening of the Session and Introduction

Chair persons : Hervé Perron & Jean-Louis Touraine

Introductory Presentation


Cédric Feschotte – Department of Human Genetics, University of Utah, USA
Of Good and Evil : Biological Impact of Endogenous Retroviruses and Other Invasive Genetic Elements

Neurological Diseases and HERVs

Chairpersons : Avindra Nath & Guilherme Sciascia do Olival


Avindra Nath- NIH, NINDS, Bethesda, USA
Amyotrophic Lateral Sclerosis and HERV-K


Hervé Perron- GeNeuro Innovation, Lyon, France
From the first retroviral detection in Multiple Sclerosis (MSRV) to the human endogenous retrovirus type W family (HERV-W), the association with disease and the identification of env-encoded pathogenic effector as a therapeutic target in vitro and in vivo models

Patrick Küry – University of Düsseldorf, Germany
Remyelination impairment and HERV-W in Multiple Sclerosis

Patrice Marche – U823 INSERM- University of Grenoble, France
Inflammatory response of endothelial cells to HERV-W Envelope

Antonina Dolei – University of Sassari, Italy
HERV-W/MSRV/Syncytin-1 activation and multiple sclerosis triggers : the EBV/MSRV dual virus hypothesis

Jack van Horssen- VU-University, Amsterdam, The Netherlands
HERV-W Env and Gag immunohistology in cohorts of MS and control brains

John Kriesel – University of Utah, USA
HERV RNA in MS brain

Ranjan Dutta – Cleveland Clinic, Ohio, USA
HERVs in Progressive Multiple Sclerosis

Guilherme Sciascia do Olival – University of Sao Paulo, Brazil
HERV-W/MRSV envelope transcripts detection in blood of multiple sclerosis patients after Natalizumab treatment

Alain Créange – University Hospital Henri Mondor, Créteil, France
Chronic Inflammatory Demyelinating Polyneuropathies and HERV-W

Raphaël Faucard – GeNeuro Innovation, France
MSRV envelope protein is a highly potent agonist of human TLR4: relevance of GNbAC1 in Chronic Inflammatory Demyelinating Diseases treatment

Alexander Emmer & Malte Kornhuber – Martin-Luther-University Halle-Wittenberg, Germany
HERV encoded envelope proteins – key players in autoimmunity ?

Hervé Porchet – GeNeuro SA, Switzerland;
GNbAC1, a humanized IgG4 antibody neutralizing HERV-W Envelope protein; pre-clinical development and Results from Phase I/IIa clinical trials in Healthy volunteers and in MS patients

General discussion
Chairpersons : Patrick Küry & Cedric Feschotte

Conclusions and end of the session
Chairpersons : Patrice Marche & Hervé Perron



Wednesday 27th May 2015

Welcome of the participants and coffee

Introductory Presentation

Chairpersons : Antonina Dolei & Patrice Marche

Frédéric Arnaud – University of Lyon, France and MRC-Center for Virus Research, Glasgow-UK
“Friendly viruses”: antiviral activities of ERVs against the oncogenic Jaagsiekte sheep retrovirus,  the etiologic agent responsible for ovine pulmonary adenocarcinoma in sheep
Virus interplay with HERV Pathogeny
Elena Uleri – University of Sassari, Italy
HERV-W/Syncytin- 1 regulation by HIV-tat in blood and brain cells is mediated by Toll-like receptor 4 and TNF-alpha: inference for neuroAIDS
Benjamin Charvet – International Center for Infectiology Research/INSERM U1111/ENS/University of Lyon, France HHV-6A infection induces the expression of HERV-W envelope in human cells

Neuropsychiatric Diseases and HERVs

Chairpersons : Hakan Kalsson & Laurent Groc

Hakan Karlsson- Karolinska Institute, Sweden HERV-W in Schizophenia
Laurent Groc – University of Bordeaux, France
Molecular imaging and specific neuronoglial reactivity to HERV-W Envelope
Nora Hamdani – APHP & University of Créteil, France Inflammatory psychoses and HERV-W
Chiara Cipriani – University of Rome & Istituto Superiore di Sanita, Italy Transcriptional activity of different endogenous retrovirus families in a mouse model of autism

Diabetes and HERVs

Chairperson : Marion Schneider

13h40-14h05 Marion Schneider – University of Ulm, Germany
HERV-W expression in immature dendritic cells from diabetes
14h05-14h30 Julie Medina – GeNeuro Innovation, Lyon, France
Jacques Portoukalian – University of Lyon, France
Human Endogenous Retrovirus type W is strongly upregulated in T1D pancreas and dysregulates insulin production in vitro and in vivo

Cancer and HERVs

Chairperson : François Mallet

François Mallet – BioMérieux, Hospices Civils de Lyon, France
From sketches of the HERV transcriptome landscape to the clinical evidence of HERV-H specific retroviruses expression in colorectal carcinoma
Reiner Strick – University Clinic Erlangen, Germany
Dysregulation of ERV genes in human pituitary adenoma and glioblastoma multiforme : Possible
functional role in giant-cell glioblastoma
Claudia Matteucci – University of Rome & National Research Council, Italy
Involvement of HERV-K in stemness and malignancy of human melanoma
Martin Staege – Martin-Luther-University Halle-Wittenberg, Germany
HERVs and Hodgkins-lymphoma
General Discussion
Chaipersons : Hervé Perron & François Mallet
Conclusions and End of the meeting
Chairpersons : Patrice Marche, François Curtin & Hervé Perron

(The name of speakers is given for presentations. All authors will be mentioned with titles in the abstract book)


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